Anti-aging pathway enhances cell stress response

Biotechnology - General

Anti-aging pathway enhances cell stress response

http://www.eurekalert.org/pub_releases/2009-02/nu-ape021909.php
Scanned by: Garry Golden over 4 years ago

Northwestern University researchers studied the effect of resveratrol, a beneficial chemical found in red wine, on human cells in tissue culture. The findings may help explain what happens in neurodegenerative diseases, which are age-related, when cell protection fails, proteins misfold, lots of damage accumulates and the system falls apart. The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. Regulation of this pathway has a direct beneficial effect to cells, the research shows.

Type: Discovery | Also: Health & Medicine, Science, Aging |

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Anti-aging pathway enhances cell stress response

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